Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs

RATIONALE: The molecular mechanisms underlying the muscle atrophy of intensive care unit-acquired weakness (ICUAW) are poorly understood. We hypothesised that increased circulating and muscle growth and differentiation factor-15 (GDF-15) causes atrophy in ICUAW by changing expression of key microRNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Bloch, S A A, Lee, J Y, Syburra, T, Rosendahl, U, Griffiths, M J D, Kemp, P R, Polkey, M I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Critical Care
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345798/
https://www.ncbi.nlm.nih.gov/pubmed/25516419
http://dx.doi.org/10.1136/thoraxjnl-2014-206225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345798/
https://www.ncbi.nlm.nih.gov/pubmed/25516419
http://dx.doi.org/10.1136/thoraxjnl-2014-206225

Ejemplares similares