NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis

OBJECTIVE: Hypoxia-inducible factor 2α (HIF-2α), encoded by Epas1, causes osteoarthritic cartilage destruction by regulating the expression of matrix-degrading enzymes. We undertook this study to explore the role of nicotinamide phosphoribosyltransferase (NAMPT or visfatin) in HIF-2α-mediated osteoa...

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Detalles Bibliográficos
Autores principales: Yang, Siyoung, Ryu, Je-Hwang, Oh, Hwanhee, Jeon, Jimin, Kwak, Ji-Sun, Kim, Jin-Hong, Kim, Hyun Ah, Chun, Churl-Hong, Chun, Jang-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345811/
https://www.ncbi.nlm.nih.gov/pubmed/24347567
http://dx.doi.org/10.1136/annrheumdis-2013-204355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345811/
https://www.ncbi.nlm.nih.gov/pubmed/24347567
http://dx.doi.org/10.1136/annrheumdis-2013-204355

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