Overexpression of PAK1 Promotes Cell Survival in Inflammatory Bowel Diseases and Colitis-associated Cancer

BACKGROUND: Chronic gut inflammation predisposes to the development of colorectal cancer and increased mortality. Use of mesalamine (5-ASA) in the treatment of ulcerative colitis modulates the risk of neoplastic progression. p21 activated kinase 1 (PAK1) mediates 5-ASA activity by orchestrating MAPK...

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Detalles Bibliográficos
Autores principales: Khare, Vineeta, Dammann, Kyle, Asboth, Mario, Krnjic, Anita, Jambrich, Manuela, Gasche, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345971/
https://www.ncbi.nlm.nih.gov/pubmed/25569743
http://dx.doi.org/10.1097/MIB.0000000000000281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345971/
https://www.ncbi.nlm.nih.gov/pubmed/25569743
http://dx.doi.org/10.1097/MIB.0000000000000281

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