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Overexpression of PAK1 Promotes Cell Survival in Inflammatory Bowel Diseases and Colitis-associated Cancer

BACKGROUND: Chronic gut inflammation predisposes to the development of colorectal cancer and increased mortality. Use of mesalamine (5-ASA) in the treatment of ulcerative colitis modulates the risk of neoplastic progression. p21 activated kinase 1 (PAK1) mediates 5-ASA activity by orchestrating MAPK...

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Detalles Bibliográficos
Autores principales:	Khare, Vineeta, Dammann, Kyle, Asboth, Mario, Krnjic, Anita, Jambrich, Manuela, Gasche, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345971/ https://www.ncbi.nlm.nih.gov/pubmed/25569743 http://dx.doi.org/10.1097/MIB.0000000000000281

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