Cargando…

Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling

Despite the widespread application of silica nanoparticles (SiNPs) in industrial, commercial, and biomedical fields, their response to human cells has not been fully elucidated. Overall, little is known about the toxicological effects of SiNPs on the cardiovascular system. In this study, SiNPs with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Caixia, Xia, Yinye, Niu, Piye, Jiang, Lizhen, Duan, Junchao, Yu, Yang, Zhou, Xianqing, Li, Yanbo, Sun, Zhiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345992/ https://www.ncbi.nlm.nih.gov/pubmed/25759575 http://dx.doi.org/10.2147/IJN.S76114

Ejemplares similares

Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling
por: Guo, Caixia, et al.
Publicado: (2016)

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway
por: Duan, Junchao, et al.
Publicado: (2014)

Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint
por: Duan, Junchao, et al.
Publicado: (2013)

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis
por: Duan, Junchao, et al.
Publicado: (2014)

Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE(−/−) mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage
por: Ma, Ru, et al.
Publicado: (2020)

Toxic Effects of Silica Nanoparticles on Zebrafish Embryos and Larvae
por: Duan, Junchao, et al.
Publicado: (2013)

DNA Hypermethylation of CREB3L1 and Bcl-2 Associated with the Mitochondrial-Mediated Apoptosis via PI3K/Akt Pathway in Human BEAS-2B Cells Exposure to Silica Nanoparticles
por: Zou, Yang, et al.
Publicado: (2016)

Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments
por: Xiao, Liyan, et al.
Publicado: (2023)

Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway
por: Feng, Lin, et al.
Publicado: (2019)

Silica nanoparticles induce reversible damage of spermatogenic cells via RIPK1 signal pathways in C57 mice
por: Ren, Lihua, et al.
Publicado: (2016)

Oxidative Damage and Energy Metabolism Disorder Contribute to the Hemolytic Effect of Amorphous Silica Nanoparticles
por: Jiang, Lizhen, et al.
Publicado: (2016)

Acute Toxicity of Amorphous Silica Nanoparticles in Intravenously Exposed ICR Mice
por: Yu, Yang, et al.
Publicado: (2013)

Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo
por: Yu, Yang, et al.
Publicado: (2019)

Silica nanoparticles induce liver fibrosis via TGF-β(1)/Smad3 pathway in ICR mice
por: Yu, Yang, et al.
Publicado: (2017)

Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes
por: Wang, Ji, et al.
Publicado: (2017)

Combined Effect of Silica Nanoparticles and Benzo[a]pyrene on Cell Cycle Arrest Induction and Apoptosis in Human Umbilical Vein Endothelial Cells
por: Asweto, Collins Otieno, et al.
Publicado: (2017)

Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro
por: Duan, Junchao, et al.
Publicado: (2018)

Multinucleation and cell dysfunction induced by amorphous silica nanoparticles in an L-02 human hepatic cell line
por: Wang, Wen, et al.
Publicado: (2013)

The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis
por: Huang, Zixia, et al.
Publicado: (2022)

Inflammation–coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos
por: Duan, Junchao, et al.
Publicado: (2018)

Histidine‐rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF‐κB and MAPK signal pathway
por: Gao, Shangze, et al.
Publicado: (2019)

Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system
por: Feng, Lin, et al.
Publicado: (2018)

Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways
por: Xu, Chang, et al.
Publicado: (2022)

Downregulation of cathepsin C alleviates endothelial cell dysfunction by suppressing p38 MAPK/NF-κB pathway in preeclampsia
por: Lu, Fan, et al.
Publicado: (2022)

Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
por: Yang, Man, et al.
Publicado: (2016)

The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
por: Dong, Xuemeng, et al.
Publicado: (2020)

Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway
por: Wang, Mengyao, et al.
Publicado: (2023)

Effects of Launaea sarmentosa Extract on Lipopolysaccharide-Induced Inflammation via Suppression of NF-κB/MAPK Signaling and Nrf2 Activation
por: Nguyen, Thanh Q. C., et al.
Publicado: (2020)

Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling
por: He, Hui, et al.
Publicado: (2016)

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction
por: Sharma, Arpeeta, et al.
Publicado: (2017)

Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress
por: Abulikemu, Alimire, et al.
Publicado: (2022)

Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade
por: Alam, Md Badrul, et al.
Publicado: (2020)

Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells
por: Hsieh, Chung-Yu, et al.
Publicado: (2009)

Effects of andrographolide on postoperative cognitive dysfunction and the association with NF-κB/MAPK pathway
por: Ding, Yongbo, et al.
Publicado: (2017)

Plantamajoside from Plantago asiatica modulates human umbilical vein endothelial cell dysfunction by glyceraldehyde-induced AGEs via MAPK/NF-κB
por: Son, Won-rak, et al.
Publicado: (2017)

Abstract 118: Nrf2 Deficiency is Associated with Endothelial Dysfunction in Pathologic Wound Environments
por: Sultan, Darren, et al.
Publicado: (2018)

Eupatilin Suppresses OVA-Induced Asthma by Inhibiting NF-κB and MAPK and Activating Nrf2 Signaling Pathways in Mice
por: Bai, Donghui, et al.
Publicado: (2022)

Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPK/Nrf-2/HO-1/NF-κB In Vitro and In Vivo
por: Liu, Kun, et al.
Publicado: (2019)

Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway
por: Liu, Chang, et al.
Publicado: (2019)

Nuclear Signaling of Plant MAPKs
por: Bigeard, Jean, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_cvjfnfbso1p0ja3niiktpaapma