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Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing
BACKGROUND: The extent to which metastatic tumors further evolve by accumulating additional mutations is unclear and has yet to be addressed extensively using next-generation sequencing of high-grade serous ovarian cancer. METHODS: Eleven spatially separated tumor samples from the primary tumor and...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346117/ https://www.ncbi.nlm.nih.gov/pubmed/25881093 http://dx.doi.org/10.1186/s12885-015-1077-4 |