Cargando…

Naïve T-cells in Myelodysplastic Syndrome Display Intrinsic Human Telomerase Reverse Transcriptase (hTERT) Deficiency

Telomeres are specialized structures providing chromosome integrity during cellular division along with protection against premature senescence and apoptosis. Accelerated telomere attrition in patients with Myelodysplastic Syndrome (MDS) occurs by an undefined mechanism. Although the MDS clone origi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Lili, Mailloux, Adam, Rollison, Dana E., Painter, Jeffrey S., Maciejewski, Jaroslaw, Paquette, Ronald L., Loughran, Thomas P., McGraw, Kathy, Makishima, Hideki, Radhakrishnan, Rangasudhagar, Wei, Sheng, Ren, Xiubao, Komrokji, Rami, List, Alan F., Epling-Burnette, P.K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346223/ https://www.ncbi.nlm.nih.gov/pubmed/23072779 http://dx.doi.org/10.1038/leu.2012.300

Ejemplares similares

Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours
por: Lantuejoul, S, et al.
Publicado: (2004)

Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
por: Ramlee, Muhammad Khairul, et al.
Publicado: (2016)

TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del(5q) myelodysplastic syndromes
por: McGraw, Kathy L., et al.
Publicado: (2015)

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer
por: Yang, Ruozhu, et al.
Publicado: (2023)

MDS shows a higher expression of hTERT and alternative splice variants in unactivated T-cells
por: Dong, Wen, et al.
Publicado: (2016)

Human Telomerase Reverse Transcriptase (hTERT) Q169 Is Essential for Telomerase Function In Vitro and In Vivo
por: Wyatt, Haley D. M., et al.
Publicado: (2009)

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
por: Leão, Ricardo, et al.
Publicado: (2018)

Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia
por: Yik, Mot Yee, et al.
Publicado: (2021)

Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes
por: Dong, Wen, et al.
Publicado: (2016)

Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
por: Mailloux, Adam W., et al.
Publicado: (2013)

Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms
por: Xu, D, et al.
Publicado: (1999)

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
por: Plyasova, Anna A., et al.
Publicado: (2021)

Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter
por: Gu, Wei, et al.
Publicado: (2022)

Copy-number-gain of telomerase reverse transcriptase (hTERT) is associated with an unfavorable prognosis in esophageal adenocarcinoma
por: Lyu, Su Ir, et al.
Publicado: (2023)

Immune dysregulation in myelodysplastic syndrome
por: Sugimori, Chiharu, et al.
Publicado: (2010)

HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)
por: Kuhlmann, Anne-Sophie, et al.
Publicado: (2007)

Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene
por: Zhu, Qingjun, et al.
Publicado: (2008)

Proteomic identification of proteins differentially expressed following overexpression of hTERT (human telomerase reverse transcriptase) in cancer cells
por: Jaiswal, Rishi Kumar, et al.
Publicado: (2017)

Reversal of T-cell Tolerance in Myelodysplastic Syndrome through Lenalidomide Immune Modulation
por: McDaniel, Jessica M., et al.
Publicado: (2011)

mRNA quantification and clinical evaluation of telomerase reverse transcriptase subunit (hTERT) in intracranial tumours of patients in the island of Crete
por: Yannopoulos, A, et al.
Publicado: (2005)

Expression Pattern of Telomerase Reverse Transcriptase (hTERT) Variants and Bcl-2 in Peripheral Lymphocytes of Systemic Lupus Erythematosus Patients
por: Attar, Armin, et al.
Publicado: (2020)

Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells
por: Khosravi- Maharlooei, Mohsen, et al.
Publicado: (2015)

Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression
por: Tang, Bo, et al.
Publicado: (2015)

In silico Analysis of Human Telomerase Reverse Transcriptase (hTERT) Gene: Identification of a Distant Homolog of Melanoma Antigen Family Gene (MAGE)
por: Amin, Ruhul, et al.
Publicado: (2009)

Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism
por: La, Sun-Hyuk, et al.
Publicado: (2016)

hTERT promotes cell adhesion and migration independent of telomerase activity
por: Liu, Haiying, et al.
Publicado: (2016)

PCDH10 Interacts With hTERT and Negatively Regulates Telomerase Activity
por: Zhou, Li-Na, et al.
Publicado: (2015)

Interferon-Inducible IFI16, a Negative Regulator of Cell Growth, Down-Regulates Expression of Human Telomerase Reverse Transcriptase (hTERT) Gene
por: Song, Lynda Li, et al.
Publicado: (2010)

Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population
por: Zhang, Jian, et al.
Publicado: (2017)

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
por: Khattar, Ekta, et al.
Publicado: (2017)

Effects of hTERT transfection on the telomere and telomerase of Periplaneta americana cells in vitro
por: Ma, Chenjing, et al.
Publicado: (2023)

The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
por: Li, Jian-Jun, et al.
Publicado: (2017)

Evaluation of Energy Balance on Human Telomerase Reverse Transcriptase (hTERT) Alternative Splicing by Semi-quantitative RT-PCR in Human Umbilical Vein Endothelial Cells
por: Behjati, Mohaddeseh, et al.
Publicado: (2017)

Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics
por: Yuan, Xiaotian, et al.
Publicado: (2019)

Many disease-associated variants of hTERT retain high telomerase enzymatic activity
por: Zaug, Arthur J., et al.
Publicado: (2013)

Hormonal regulation of telomerase activity and hTERT expression in steroid-regulated tissues and cancer
por: Taheri, Mohammad, et al.
Publicado: (2022)

hTERT deficiency in naïve T cells affects lymphocyte homeostasis in myelodysplastic syndrome patients
por: Yang, Lili, et al.
Publicado: (2013)

Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues
por: Sæbøe-Larssen, Stein, et al.
Publicado: (2006)

Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review
por: McKelvey, Brittany A., et al.
Publicado: (2020)

The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes
por: McGraw, K L, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_e9nvjd0qo5500kpqff4bk0un14