β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells

An F-box protein, β-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene. Although the regulation by β-TrCP has been widely studied, the regulation of...

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Detalles Bibliográficos
Autores principales: Yi, Yong Weon, Kang, Hyo Jin, Bae, Edward Jeong, Oh, Seunghoon, Seong, Yeon-Sun, Bae, Insoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346488/
https://www.ncbi.nlm.nih.gov/pubmed/25721419
http://dx.doi.org/10.1038/emm.2014.127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346488/
https://www.ncbi.nlm.nih.gov/pubmed/25721419
http://dx.doi.org/10.1038/emm.2014.127

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