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Dendritic geometry shapes neuronal cAMP signalling to the nucleus

Neurons have complex dendritic trees, receiving numerous inputs at various distances from the cell body. Yet the rules of molecular signal propagation from dendrites to nuclei are unknown. DARPP-32 is a phosphorylation-regulated signalling hub in striatal output neurons. We combine diffusion-reactio...

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Detalles Bibliográficos
Autores principales: Li, Lu, Gervasi, Nicolas, Girault, Jean-Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346624/
https://www.ncbi.nlm.nih.gov/pubmed/25692798
http://dx.doi.org/10.1038/ncomms7319