Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo

Reactivation of wild-type p53 (wt-p53) function is an attractive therapeutic approach to p53-defective cancers. An ideal p53-based gene therapy should restore wt-p53 production and reduces mutant p53 transcripts simultaneously. In this study, we described an alternative strategy named as trans-splic...

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Detalles Bibliográficos
Autores principales: He, Xingxing, Liu, Fang, Yan, Jingjun, Zhang, Yunan, Yan, Junwei, Shang, Haitao, Dou, Qian, Zhao, Qiu, Song, Yuhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346796/
https://www.ncbi.nlm.nih.gov/pubmed/25732051
http://dx.doi.org/10.1038/srep08705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346796/
https://www.ncbi.nlm.nih.gov/pubmed/25732051
http://dx.doi.org/10.1038/srep08705

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