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Spatial and Cellular Characterization of mTORC1 Activation after Spinal Cord Injury Reveals Biphasic Increase Mainly Attributed to Microglia/Macrophages

Mechanistic target of rapamycin complex 1 (mTORC1) is an intracellular kinase complex that regulates energy homeostasis and transcription. Modulation of mTORC1 has proven beneficial in experimental spinal cord injury, making this molecular target a candidate for therapeutic intervention in spinal co...

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Detalles Bibliográficos
Autores principales: Kjell, Jacob, Codeluppi, Simone, Josephson, Anna, Abrams, Mathew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347463/
https://www.ncbi.nlm.nih.gov/pubmed/24576152
http://dx.doi.org/10.1111/bpa.12135