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Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More?
The induction of central tolerance in the course of T cell development crucially depends on promiscuous gene expression (pGE) in medullary thymic epithelial cells (mTECs). mTECs express a genome-wide variety of tissue-restricted antigens (TRAs), preventing the escape of autoreactive T cells to the p...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347492/ https://www.ncbi.nlm.nih.gov/pubmed/25784915 http://dx.doi.org/10.3389/fimmu.2015.00093 |