A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

BACKGROUND: Presentation of identical HIV-1 peptides by closely related Human Leukocyte Antigen class I (HLAI) molecules can select distinct patterns of escape mutation that have a significant impact on viral fitness and disease progression. The molecular mechanisms by which HLAI micropolymorphisms...

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Detalles Bibliográficos
Autores principales: Kløverpris, Henrik N, Cole, David K, Fuller, Anna, Carlson, Jonathan, Beck, Konrad, Schauenburg, Andrea J, Rizkallah, Pierre J, Buus, Søren, Sewell, Andrew K, Goulder, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347545/
https://www.ncbi.nlm.nih.gov/pubmed/25808313
http://dx.doi.org/10.1186/s12977-015-0149-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347545/
https://www.ncbi.nlm.nih.gov/pubmed/25808313
http://dx.doi.org/10.1186/s12977-015-0149-5

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