Cargando…

DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior

The small guanosine triphosphatase Rab13 functions in exocytic vesicle trafficking in epithelial cells. Alterations in Rab13 activity have been observed in human cancers, yet the mechanism of Rab13 activation and its role in cancer progression remain unclear. In this paper, we identify the DENN doma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ioannou, Maria S., Bell, Emily S., Girard, Martine, Chaineau, Mathilde, Hamlin, Jason N.R., Daubaras, Mark, Monast, Anie, Park, Morag, Hodgson, Louis, McPherson, Peter S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347646/ https://www.ncbi.nlm.nih.gov/pubmed/25713415 http://dx.doi.org/10.1083/jcb.201407068

Ejemplares similares

Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton
por: Marat, Andrea L., et al.
Publicado: (2012)

An Arf/Rab cascade controls the growth and invasiveness of glioblastoma
por: Kulasekaran, Gopinath, et al.
Publicado: (2021)

EGF Stimulates Rab35 Activation and Gastric Cancer Cell Migration by Regulating DENND1A-Grb2 Complex Formation
por: Ye, Bixing, et al.
Publicado: (2018)

Rab-mediated membrane trafficking and the control of epithelial cell polarity
por: Ioannou, Maria S., et al.
Publicado: (2016)

Mapping the Interactions between a RUN Domain from DENND5/Rab6IP1 and Sorting Nexin 1
por: Fernandes, Humberto, et al.
Publicado: (2012)

A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis
por: Kumar, Rahul, et al.
Publicado: (2022)

DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass
por: Gordon, Scott M., et al.
Publicado: (2019)

Met–HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells
por: Stern, Yaakov E., et al.
Publicado: (2022)

Genetic Alterations within the DENND1A Gene in Patients with Polycystic Ovary Syndrome (PCOS)
por: Eriksen, Mette B., et al.
Publicado: (2013)

Association of DENND1A Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis
por: Bao, Shan, et al.
Publicado: (2016)

Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis
por: Larsen, Celina Bakke, et al.
Publicado: (2023)

Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia
por: Ren, Shasha, et al.
Publicado: (2019)

Co-dependency for MET and FGFR1 in basal triple-negative breast cancers
por: Sung, Vanessa Y. C., et al.
Publicado: (2021)

Cancer driver candidate genes AVL9, DENND5A and NUPL1 contribute to MDCK cystogenesis
por: Li, Yaping, et al.
Publicado: (2014)

DOCK11 and DENND2A play pivotal roles in the maintenance of hepatitis B virus in host cells
por: Hashimoto, Shinichi, et al.
Publicado: (2021)

circDENND4C Promotes Proliferation and Metastasis of Lung Cancer by Upregulating BRD4 Signaling Pathway
por: Ma, Dongjie, et al.
Publicado: (2021)

Dennd5b-Deficient Mice are Resistant to PCSK9-Induced Hypercholesterolemia and Diet-Induced Hepatic Steatosis
por: Mobilia, Maura, et al.
Publicado: (2022)

MEDB-64. Are Rab GTPases metastatic drivers in metastatic medulloblastoma?
por: Entwistle, Susannah, et al.
Publicado: (2022)

Hypoxia-associated circDENND2A promotes glioma aggressiveness by sponging miR-625-5p
por: Su, Hui, et al.
Publicado: (2019)

chi-miR-324-3p Regulates Goat Granulosa Cell Proliferation by Targeting DENND1A
por: Liu, Yufang, et al.
Publicado: (2021)

Stage IV colon cancer patients without DENND2D expression benefit more from neoadjuvant chemotherapy
por: Ma, Wen-juan, et al.
Publicado: (2022)

Crk adaptor proteins act as key signaling integrators for breast tumorigenesis
por: Fathers, Kelly E, et al.
Publicado: (2012)

The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS
por: Castellanos-Montiel, María José, et al.
Publicado: (2020)

KHDRBS3 regulates the permeability of blood–tumor barrier via cDENND4C/miR-577 axis
por: Wu, Peiqi, et al.
Publicado: (2019)

FRI455 Polycystic Ovary Syndrome-Associated DENND1A Non-Coding Risk Loci Alter Gene Expression
por: Sankaranarayanan, Laavanya, et al.
Publicado: (2023)

A Rab-bit hole: Rab40 GTPases as new regulators of the actin cytoskeleton and cell migration
por: Neumann, Andrew J., et al.
Publicado: (2023)

Cell coordination of collective migration by Rab11 and Moesin
por: Emery, Gregory, et al.
Publicado: (2013)

5′-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion
por: Rajadurai, Charles V., et al.
Publicado: (2016)

Human DENND1A.V2 Drives Cyp17a1 Expression and Androgen Production in Mouse Ovaries and Adrenals
por: Teves, Maria E., et al.
Publicado: (2020)

Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women
por: Zhu, Ya-nan, et al.
Publicado: (2020)

CircNFIC Balances Inflammation and Apoptosis by Sponging miR-30e-3p and Regulating DENND1B Expression
por: Chen, Yangfeng, et al.
Publicado: (2021)

Rab7b at the intersection of intracellular trafficking and cell migration
por: Distefano, Marita Borg, et al.
Publicado: (2015)

PCOS-GWAS Susceptibility Variants in THADA, INSR, TOX3, and DENND1A Are Associated With Metabolic Syndrome or Insulin Resistance in Women With PCOS
por: Tian, Ye, et al.
Publicado: (2020)

Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma
por: Sakha, Sujata, et al.
Publicado: (2016)

Cholesterol-Induced Metabolic Reprogramming in Breast Cancer Cells Is Mediated via the ERRα Pathway
por: Ghanbari, Faegheh, et al.
Publicado: (2021)

Scyl1 Regulates Golgi Morphology
por: Burman, Jonathon L., et al.
Publicado: (2010)

Mechanisms of leading edge protrusion in interstitial migration
por: Wilson, Kerry, et al.
Publicado: (2013)

The Specification of Geometric Edges by a Plant Rab GTPase Is an Essential Cell-Patterning Principle During Organogenesis in Arabidopsis
por: Kirchhelle, Charlotte, et al.
Publicado: (2016)

CircDENND2A Promotes Non-small Cell Lung Cancer Progression via Regulating MiR-34a/CCNE1 Signaling
por: Zhang, Yinbin, et al.
Publicado: (2020)

The ARSACS disease protein sacsin controls lysosomal positioning and reformation by regulating microtubule dynamics
por: Francis, Vincent, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ll3d6ovua036ub8fho11tckhgl