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Structure of precursor microRNA’s terminal loop regulates human Dicer’s dicing activity by switching DExH/D domain
Almost all pre-miRNAs in eukaryotic cytoplasm are recognized and processed into double-stranded microRNAs by the endonuclease Dicer protein comprising of multiple domains. As a key player in the small RNA induced gene silencing pathway, the major domains of Dicer are conserved among different specie...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Higher Education Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348242/ https://www.ncbi.nlm.nih.gov/pubmed/25549615 http://dx.doi.org/10.1007/s13238-014-0124-2 |