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α6β1- and αV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF

BACKGROUND: The growth properties and self-renewal capacity of embryonic stem (ES) cells are regulated by their immediate microenvironment such as the extracellular matrix (ECM). Integrins, a central family of cellular ECM receptors, have been implicated in these processes but their specific role in...

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Detalles Bibliográficos
Autores principales: Cattavarayane, Sandhanakrishnan, Palovuori, Riitta, Tanjore Ramanathan, Jayendrakishore, Manninen, Aki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348401/
https://www.ncbi.nlm.nih.gov/pubmed/25886986
http://dx.doi.org/10.1186/s12860-015-0051-y