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Attenuation of Tick-Borne Encephalitis Virus Using Large-Scale Random Codon Re-encoding
Large-scale codon re-encoding (i.e. introduction of a large number of synonymous mutations) is a novel method of generating attenuated viruses. Here, it was applied to the pathogenic flavivirus, tick-borne encephalitis virus (TBEV) which causes febrile illness and encephalitis in humans in forested...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348424/ https://www.ncbi.nlm.nih.gov/pubmed/25734338 http://dx.doi.org/10.1371/journal.ppat.1004738 |