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Attenuation of Tick-Borne Encephalitis Virus Using Large-Scale Random Codon Re-encoding

Large-scale codon re-encoding (i.e. introduction of a large number of synonymous mutations) is a novel method of generating attenuated viruses. Here, it was applied to the pathogenic flavivirus, tick-borne encephalitis virus (TBEV) which causes febrile illness and encephalitis in humans in forested...

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Detalles Bibliográficos
Autores principales:	de Fabritus, Lauriane, Nougairède, Antoine, Aubry, Fabien, Gould, Ernest A, de Lamballerie, Xavier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348424/ https://www.ncbi.nlm.nih.gov/pubmed/25734338 http://dx.doi.org/10.1371/journal.ppat.1004738

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