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P2X4 receptor–eNOS signaling pathway in cardiac myocytes as a novel protective mechanism in heart failure

We have demonstrated using immunoprecipitation and immunostaining a novel physical association of the P2X4 receptor (P2X4R), a ligand-gated ion channel, with the cardioprotective, calcium-dependent enzyme endothelial nitric oxide synthase (eNOS). Treatment of murine ventricular myocytes with the P2X...

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Detalles Bibliográficos
Autores principales: Yang, Ronghua, Beqiri, Dardan, Shen, Jian-Bing, Redden, John M., Dodge-Kafka, Kimberly, Jacobson, Kenneth A., Liang, Bruce T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348440/
https://www.ncbi.nlm.nih.gov/pubmed/25750695
http://dx.doi.org/10.1016/j.csbj.2014.11.002