Effect of the excipient concentration on the pharmacokinetics of PM181104, a novel antimicrobial thiazolyl cyclic peptide antibiotic, following intravenous administration to mice

Thiazolyl cyclic peptide antibiotics are known for their poor aqueous solubility and unfavorable pharmacokinetics (PK) and hence pose challenging tasks in developing these antibiotics as clinical candidates. In the current paper, we report a possible way to address these challenges with exemplificat...

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Detalles Bibliográficos
Autores principales: Yemparala, Vijayaphanikumar, Damre, Anagha A., Manohar, Venkat, Sharan Singh, Kishori, Mahajan, Girish B., Sawant, Satish N., Deokule, Tanaji, Sivaramakrishnan, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348513/
https://www.ncbi.nlm.nih.gov/pubmed/25756005
http://dx.doi.org/10.1016/j.rinphs.2014.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348513/
https://www.ncbi.nlm.nih.gov/pubmed/25756005
http://dx.doi.org/10.1016/j.rinphs.2014.09.001

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