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The Role of Binding Site on the Mechanical Unfolding Mechanism of Ubiquitin

We apply novel atomistic simulations based on potential energy surface exploration to investigate the constant force-induced unfolding of ubiquitin. At the experimentally-studied force clamping level of 100 pN, we find a new unfolding mechanism starting with the detachment between β(5) and β(3) invo...

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Detalles Bibliográficos
Autores principales: Cao, Penghui, Yoon, Gwonchan, Tao, Weiwei, Eom, Kilho, Park, Harold S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348633/
https://www.ncbi.nlm.nih.gov/pubmed/25736913
http://dx.doi.org/10.1038/srep08757