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The Role of Binding Site on the Mechanical Unfolding Mechanism of Ubiquitin
We apply novel atomistic simulations based on potential energy surface exploration to investigate the constant force-induced unfolding of ubiquitin. At the experimentally-studied force clamping level of 100 pN, we find a new unfolding mechanism starting with the detachment between β(5) and β(3) invo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348633/ https://www.ncbi.nlm.nih.gov/pubmed/25736913 http://dx.doi.org/10.1038/srep08757 |