Cargando…
Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors
G9a is a histone lysine methyltransferase (HKMT) involved in epigenetic regulation via the installation of histone methylation marks. 6,7-Dimethoxyquinazoline analogues, such as BIX-01294, are established as potent, substrate competitive inhibitors of G9a. With an objective to identify novel chemoty...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349132/ https://www.ncbi.nlm.nih.gov/pubmed/25750706 http://dx.doi.org/10.1039/c4md00274a |