The emerging role of insulin-like growth factors in testis development and function

The insulin-like family of growth factors (IGFs) – composed of insulin, and insulin-like growth factors I (IGF1) and II (IGF2) – provides essential signals for the control of testis development and function. In the testis, IGFs act in an autocrine-paracrine manner but the extent of their actions has...

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Autores principales: Griffeth, Richard J, Bianda, Vanessa, Nef, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349729/
https://www.ncbi.nlm.nih.gov/pubmed/25780585
http://dx.doi.org/10.1186/2051-4190-24-12
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author Griffeth, Richard J
Bianda, Vanessa
Nef, Serge
author_facet Griffeth, Richard J
Bianda, Vanessa
Nef, Serge
author_sort Griffeth, Richard J
collection PubMed
description The insulin-like family of growth factors (IGFs) – composed of insulin, and insulin-like growth factors I (IGF1) and II (IGF2) – provides essential signals for the control of testis development and function. In the testis, IGFs act in an autocrine-paracrine manner but the extent of their actions has been underestimated due to redundancies at both the ligand and receptor levels, and the perinatal lethality of constitutive knockout mice. This review synthesizes the current understanding of how the IGF system regulates biological processes such as primary sex determination, testis development, spermatogenesis and steroidogenesis, and highlights the questions that remain to be explored.
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spelling pubmed-43497292015-03-16 The emerging role of insulin-like growth factors in testis development and function Griffeth, Richard J Bianda, Vanessa Nef, Serge Basic Clin Androl Review Article The insulin-like family of growth factors (IGFs) – composed of insulin, and insulin-like growth factors I (IGF1) and II (IGF2) – provides essential signals for the control of testis development and function. In the testis, IGFs act in an autocrine-paracrine manner but the extent of their actions has been underestimated due to redundancies at both the ligand and receptor levels, and the perinatal lethality of constitutive knockout mice. This review synthesizes the current understanding of how the IGF system regulates biological processes such as primary sex determination, testis development, spermatogenesis and steroidogenesis, and highlights the questions that remain to be explored. BioMed Central 2014-08-18 /pmc/articles/PMC4349729/ /pubmed/25780585 http://dx.doi.org/10.1186/2051-4190-24-12 Text en © Griffeth et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review Article
Griffeth, Richard J
Bianda, Vanessa
Nef, Serge
The emerging role of insulin-like growth factors in testis development and function
title The emerging role of insulin-like growth factors in testis development and function
title_full The emerging role of insulin-like growth factors in testis development and function
title_fullStr The emerging role of insulin-like growth factors in testis development and function
title_full_unstemmed The emerging role of insulin-like growth factors in testis development and function
title_short The emerging role of insulin-like growth factors in testis development and function
title_sort emerging role of insulin-like growth factors in testis development and function
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349729/
https://www.ncbi.nlm.nih.gov/pubmed/25780585
http://dx.doi.org/10.1186/2051-4190-24-12
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