An Enhanced In Vivo Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) Model for Quantification of Drug Metabolism Enzymes

Many of the enzymes involved in xenobiotic metabolism are maintained at a low basal level and are only synthesized in response to activation of upstream sensor/effector proteins. This induction can have implications in a variety of contexts, particularly during the study of the pharmacokinetics, pha...

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Detalles Bibliográficos
Autores principales: MacLeod, A. Kenneth, Fallon, Padraic G., Sharp, Sheila, Henderson, Colin J., Wolf, C. Roland, Huang, Jeffrey T.-J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Technological Innovation and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349992/
https://www.ncbi.nlm.nih.gov/pubmed/25561501
http://dx.doi.org/10.1074/mcp.M114.043661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349992/
https://www.ncbi.nlm.nih.gov/pubmed/25561501
http://dx.doi.org/10.1074/mcp.M114.043661

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