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Basal Gnathostomes Provide Unique Insights into the Evolution of Vitamin B12 Binders

The uptake and transport of vitamin B12 (cobalamin; Cbl) in mammals involves a refined system with three evolutionarily related transporters: transcobalamin 1 (Tcn1), transcobalamin 2 (Tcn2), and the gastric intrinsic factor (Gif). Teleosts have a single documented binder with intermediate features...

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Detalles Bibliográficos
Autores principales: Lopes-Marques, Mónica, Ruivo, Raquel, Delgado, Inês, Wilson, Jonathan M., Aluru, Neelakanteswar, Castro, L. Filipe C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350170/
https://www.ncbi.nlm.nih.gov/pubmed/25552533
http://dx.doi.org/10.1093/gbe/evu289