Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction

BACKGROUND: Chronic myeloid leukemia (CML) is driven by the expression of the BCR-ABL oncoprotein. STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylation in CML cells. Activated STAT5 (pSTAT5) drives proliferation and survival of leukemic cells and contributes to initial...

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Detalles Bibliográficos
Autores principales: Fahrenkamp, Dirk, de Leur, Hildegard Schmitz-Van, Küster, Andrea, Chatain, Nicolas, Müller-Newen, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350284/
https://www.ncbi.nlm.nih.gov/pubmed/25885255
http://dx.doi.org/10.1186/s12964-014-0081-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350284/
https://www.ncbi.nlm.nih.gov/pubmed/25885255
http://dx.doi.org/10.1186/s12964-014-0081-7

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