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Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction

BACKGROUND: Chronic myeloid leukemia (CML) is driven by the expression of the BCR-ABL oncoprotein. STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylation in CML cells. Activated STAT5 (pSTAT5) drives proliferation and survival of leukemic cells and contributes to initial...

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Detalles Bibliográficos
Autores principales:	Fahrenkamp, Dirk, de Leur, Hildegard Schmitz-Van, Küster, Andrea, Chatain, Nicolas, Müller-Newen, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350284/ https://www.ncbi.nlm.nih.gov/pubmed/25885255 http://dx.doi.org/10.1186/s12964-014-0081-7

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