Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion

Phorbol ester (PMA or TPA), a tumor promoter, can cause either proliferation or cell cycle arrest, depending on cellular context. For example, in SKBr3 breast cancer cells, PMA hyper-activates the MEK/MAPK pathway, thus inducing p21 and cell cycle arrest. Here we showed that PMA-induced arrest was f...

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Detalles Bibliográficos
Autores principales: Leontieva, Olga V., Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350340/
https://www.ncbi.nlm.nih.gov/pubmed/25587030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350340/
https://www.ncbi.nlm.nih.gov/pubmed/25587030

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