The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity

We previously identified TRAIL-inducing compound 10 (TIC10), also known as NSC350625 or ONC201, from a NCI chemical library screen as a small molecule that has potent anti-tumor efficacy and a benign safety profile in preclinical cancer models. The chemical structure that was originally published by...

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Detalles Bibliográficos
Autores principales: Wagner, Jessica, Kline, Christina Leah, Pottorf, Richard S., Nallaganchu, Bhaskara Rao, Olson, Gary L., Dicker, David T., Allen, Joshua E., El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350349/
https://www.ncbi.nlm.nih.gov/pubmed/25587031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350349/
https://www.ncbi.nlm.nih.gov/pubmed/25587031

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