Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

Reliance on glycolysis is a characteristic of malignancy, yet the development of resistance to BRAF inhibitors in melanoma is associated with gain of mitochondrial function. Concurrent attenuation of oxidative phosphorylation and HIF-1α/PKM2-dependent glycolysis promotes a non-apoptotic, iron- and o...

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Detalles Bibliográficos
Autores principales: Lakhter, Alexander J., Hamilton, James, Dagher, Pierre C., Mukkamala, Suresh, Hato, Takashi, Dong, X. Charlie, Mayo, Lindsey D., Harris, Robert A., Shekhar, Anantha, Ivan, Mircea, Brustovetsky, Nickolay, Naidu, Samisubbu R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350353/
https://www.ncbi.nlm.nih.gov/pubmed/25587028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350353/
https://www.ncbi.nlm.nih.gov/pubmed/25587028

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