Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

Intratumoral hypoxia, which is associated with breast cancer metastasis and patient mortality, increases the percentage of breast cancer stem cells (BCSCs) but the underlying molecular mechanisms have not been delineated. Here we report that hypoxia-inducible factor 1 (HIF-1) triggers the expression...

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Detalles Bibliográficos
Autores principales: Xiang, Lisha, Gilkes, Daniele M., Hu, Hongxia, Takano, Naoharu, Luo, Weibo, Lu, Haiquan, Bullen, John W., Samanta, Debangshu, Liang, Houjie, Semenza, Gregg L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350363/
https://www.ncbi.nlm.nih.gov/pubmed/25587023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350363/
https://www.ncbi.nlm.nih.gov/pubmed/25587023

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