Crystal structure of N-{N-[N-acetyl-(S)-leuc­yl]-(S)-leuc­yl}norleucinal (ALLN), an inhibitor of proteasome

The title compound, C(20)H(37)N(3)O(4), also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. The crystal structure of ALLN, solved from synch...

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Autores principales: Czerwinski, Andrzej, Basava, Channa, Dauter, Miroslawa, Dauter, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350719/
https://www.ncbi.nlm.nih.gov/pubmed/25844180
http://dx.doi.org/10.1107/S2056989015002091
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author Czerwinski, Andrzej
Basava, Channa
Dauter, Miroslawa
Dauter, Zbigniew
author_facet Czerwinski, Andrzej
Basava, Channa
Dauter, Miroslawa
Dauter, Zbigniew
author_sort Czerwinski, Andrzej
collection PubMed
description The title compound, C(20)H(37)N(3)O(4), also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. The crystal structure of ALLN, solved from synchrotron radiation diffraction data, revealed the mol­ecules in extended conformation of the backbone and engaging all peptide N and O atoms in inter­molecular hydrogen bonds forming an infinite anti­parallel β-sheet.
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spelling pubmed-43507192015-04-03 Crystal structure of N-{N-[N-acetyl-(S)-leuc­yl]-(S)-leuc­yl}norleucinal (ALLN), an inhibitor of proteasome Czerwinski, Andrzej Basava, Channa Dauter, Miroslawa Dauter, Zbigniew Acta Crystallogr E Crystallogr Commun Research Communications The title compound, C(20)H(37)N(3)O(4), also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. The crystal structure of ALLN, solved from synchrotron radiation diffraction data, revealed the mol­ecules in extended conformation of the backbone and engaging all peptide N and O atoms in inter­molecular hydrogen bonds forming an infinite anti­parallel β-sheet. International Union of Crystallography 2015-02-07 /pmc/articles/PMC4350719/ /pubmed/25844180 http://dx.doi.org/10.1107/S2056989015002091 Text en © Czerwinski et al. 2015 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Communications
Czerwinski, Andrzej
Basava, Channa
Dauter, Miroslawa
Dauter, Zbigniew
Crystal structure of N-{N-[N-acetyl-(S)-leuc­yl]-(S)-leuc­yl}norleucinal (ALLN), an inhibitor of proteasome
title Crystal structure of N-{N-[N-acetyl-(S)-leuc­yl]-(S)-leuc­yl}norleucinal (ALLN), an inhibitor of proteasome
title_full Crystal structure of N-{N-[N-acetyl-(S)-leuc­yl]-(S)-leuc­yl}norleucinal (ALLN), an inhibitor of proteasome
title_fullStr Crystal structure of N-{N-[N-acetyl-(S)-leuc­yl]-(S)-leuc­yl}norleucinal (ALLN), an inhibitor of proteasome
title_full_unstemmed Crystal structure of N-{N-[N-acetyl-(S)-leuc­yl]-(S)-leuc­yl}norleucinal (ALLN), an inhibitor of proteasome
title_short Crystal structure of N-{N-[N-acetyl-(S)-leuc­yl]-(S)-leuc­yl}norleucinal (ALLN), an inhibitor of proteasome
title_sort crystal structure of n-{n-[n-acetyl-(s)-leuc­yl]-(s)-leuc­yl}norleucinal (alln), an inhibitor of proteasome
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350719/
https://www.ncbi.nlm.nih.gov/pubmed/25844180
http://dx.doi.org/10.1107/S2056989015002091
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