Selective inhibitors of nuclear export (SINE) in hematological malignancies

Regulated nucleo-cytoplasmic transport plays a major role in maintaining cellular homeostasis. CRM1 (chromosome region maintenance 1 or exportin 1 or XPO 1) is responsible for the nucleo-cytoplasmic transport of more than 200 proteins, including most of the tumor suppressor proteins (TSP). CRM1 is o...

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Autores principales: Das, Arundhati, Wei, Guoqing, Parikh, Kaushal, Liu, Delong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350974/
https://www.ncbi.nlm.nih.gov/pubmed/25745591
http://dx.doi.org/10.1186/s40164-015-0002-5
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author Das, Arundhati
Wei, Guoqing
Parikh, Kaushal
Liu, Delong
author_facet Das, Arundhati
Wei, Guoqing
Parikh, Kaushal
Liu, Delong
author_sort Das, Arundhati
collection PubMed
description Regulated nucleo-cytoplasmic transport plays a major role in maintaining cellular homeostasis. CRM1 (chromosome region maintenance 1 or exportin 1 or XPO 1) is responsible for the nucleo-cytoplasmic transport of more than 200 proteins, including most of the tumor suppressor proteins (TSP). CRM1 is overexpressed in pancreatic cancer, osteosarcoma, glioma, cervical and hematological malignancies. This inspired the development of novel agents that selectively inhibit nuclear exportins (SINEs). In this review we focus on the significance of CRM1 in carcinogenesis and review the new development of SINE inhibitiors in hematological malignancies. Selinexor (KPT-330) as the first-in-human SINE agent represents this novel class of anti-cancer agents.
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spelling pubmed-43509742015-03-06 Selective inhibitors of nuclear export (SINE) in hematological malignancies Das, Arundhati Wei, Guoqing Parikh, Kaushal Liu, Delong Exp Hematol Oncol Review Regulated nucleo-cytoplasmic transport plays a major role in maintaining cellular homeostasis. CRM1 (chromosome region maintenance 1 or exportin 1 or XPO 1) is responsible for the nucleo-cytoplasmic transport of more than 200 proteins, including most of the tumor suppressor proteins (TSP). CRM1 is overexpressed in pancreatic cancer, osteosarcoma, glioma, cervical and hematological malignancies. This inspired the development of novel agents that selectively inhibit nuclear exportins (SINEs). In this review we focus on the significance of CRM1 in carcinogenesis and review the new development of SINE inhibitiors in hematological malignancies. Selinexor (KPT-330) as the first-in-human SINE agent represents this novel class of anti-cancer agents. BioMed Central 2015-03-01 /pmc/articles/PMC4350974/ /pubmed/25745591 http://dx.doi.org/10.1186/s40164-015-0002-5 Text en © Das et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Das, Arundhati
Wei, Guoqing
Parikh, Kaushal
Liu, Delong
Selective inhibitors of nuclear export (SINE) in hematological malignancies
title Selective inhibitors of nuclear export (SINE) in hematological malignancies
title_full Selective inhibitors of nuclear export (SINE) in hematological malignancies
title_fullStr Selective inhibitors of nuclear export (SINE) in hematological malignancies
title_full_unstemmed Selective inhibitors of nuclear export (SINE) in hematological malignancies
title_short Selective inhibitors of nuclear export (SINE) in hematological malignancies
title_sort selective inhibitors of nuclear export (sine) in hematological malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350974/
https://www.ncbi.nlm.nih.gov/pubmed/25745591
http://dx.doi.org/10.1186/s40164-015-0002-5
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AT parikhkaushal selectiveinhibitorsofnuclearexportsineinhematologicalmalignancies
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