Sequence composition of disordered regions fine-tunes protein half-life

The proteasome controls the concentrations of most proteins in eukaryotic cells. It recognizes its protein substrates through ubiquitin tags and initiates degradation at disordered regions within the substrate. Here we find that the proteasome has pronounced preferences for the amino acid sequence c...

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Detalles Bibliográficos
Autores principales: Fishbain, Susan, Inobe, Tomonao, Israeli, Eitan, Chavali, Sreenivas, Yu, Houqing, Kago, Grace, Babu, M. Madan, Matouschek, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351145/
https://www.ncbi.nlm.nih.gov/pubmed/25643324
http://dx.doi.org/10.1038/nsmb.2958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351145/
https://www.ncbi.nlm.nih.gov/pubmed/25643324
http://dx.doi.org/10.1038/nsmb.2958

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