Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation

Lysosomal dysfunction is a common pathological feature of neurodegenerative diseases. GTP-binding protein type A1 (GBA1) encodes β-glucocerebrosidase 1 (GCase 1), a lysosomal hydrolase. Homozygous mutations in GBA1 cause Gaucher disease, the most common lysosomal storage disease, while heterozygous...

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Detalles Bibliográficos
Autores principales: Bae, Eun-Jin, Yang, Na Young, Lee, Cheolsoon, Lee, He-Jin, Kim, Seokjoong, Sardi, Sergio Pablo, Lee, Seung-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351412/
https://www.ncbi.nlm.nih.gov/pubmed/25813221
http://dx.doi.org/10.1038/emm.2014.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351412/
https://www.ncbi.nlm.nih.gov/pubmed/25813221
http://dx.doi.org/10.1038/emm.2014.128

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