The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells

The phosphatidylinositol-3-kinase (PI3K) pathway is commonly hyperactivated in cancer. One mechanism by which this occurs is by silencing of the phosphatase and tensin homolog (PTEN), a tumor suppressor and major antagonist of the pathway, through genetic, epigenetic or posttranscriptional mechanism...

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Detalles Bibliográficos
Autores principales: Sacco, J J, Yau, T Y, Darling, S, Patel, V, Liu, H, Urbé, S, Clague, M J, Coulson, J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351423/
https://www.ncbi.nlm.nih.gov/pubmed/24292675
http://dx.doi.org/10.1038/onc.2013.512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351423/
https://www.ncbi.nlm.nih.gov/pubmed/24292675
http://dx.doi.org/10.1038/onc.2013.512

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