Cotranslational Folding Inhibits Translocation from Within the Ribosome–Sec61 Translocon Complex

Eukaryotic secretory proteins cross the endoplasmic reticulum (ER) membrane through a protein conducting channel contained within the Ribosome–Sec61Translocon Complex (RTC). Using a zinc-finger sequence as a folding switch, we show that cotranslational folding of a secretory passenger inhibits trans...

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Detalles Bibliográficos
Autores principales: Conti, Brian J., Elferich, Johannes, Yang, Zhongying, Shinde, Ujwal, Skach, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351553/
https://www.ncbi.nlm.nih.gov/pubmed/24561504
http://dx.doi.org/10.1038/nsmb.2779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351553/
https://www.ncbi.nlm.nih.gov/pubmed/24561504
http://dx.doi.org/10.1038/nsmb.2779

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