3D hotspots of recurrent retroviral insertions reveal long-range interactions with cancer genes

Genomically distal mutations can contribute to the deregulation of cancer genes by engaging in chromatin interactions. To study this, we overlay viral cancer-causing insertions obtained in a murine retroviral insertional mutagenesis screen with genome-wide chromatin conformation capture data. Here w...

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Detalles Bibliográficos
Autores principales: Babaei, Sepideh, Akhtar, Waseem, de Jong, Johann, Reinders, Marcel, de Ridder, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351571/
https://www.ncbi.nlm.nih.gov/pubmed/25721899
http://dx.doi.org/10.1038/ncomms7381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351571/
https://www.ncbi.nlm.nih.gov/pubmed/25721899
http://dx.doi.org/10.1038/ncomms7381

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