Structural basis for self-assembly of a cytolytic pore lined by protein and lipid

Pore-forming toxins (PFT) are water-soluble proteins that possess the remarkable ability to self-assemble on the membrane of target cells, where they form pores causing cell damage. Here, we elucidate the mechanism of action of the haemolytic protein fragaceatoxin C (FraC), a α-barrel PFT, by determ...

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Detalles Bibliográficos
Autores principales: Tanaka, Koji, Caaveiro, Jose M.M., Morante, Koldo, González-Mañas, Juan Manuel, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351601/
https://www.ncbi.nlm.nih.gov/pubmed/25716479
http://dx.doi.org/10.1038/ncomms7337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351601/
https://www.ncbi.nlm.nih.gov/pubmed/25716479
http://dx.doi.org/10.1038/ncomms7337

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