BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability. Here, we show that BRCA1 is recruited to R-loops that form normally...

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Detalles Bibliográficos
Autores principales: Hatchi, Elodie, Skourti-Stathaki, Konstantina, Ventz, Steffen, Pinello, Luca, Yen, Angela, Kamieniarz-Gdula, Kinga, Dimitrov, Stoil, Pathania, Shailja, McKinney, Kristine M., Eaton, Matthew L., Kellis, Manolis, Hill, Sarah J., Parmigiani, Giovanni, Proudfoot, Nicholas J., Livingston, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351672/
https://www.ncbi.nlm.nih.gov/pubmed/25699710
http://dx.doi.org/10.1016/j.molcel.2015.01.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351672/
https://www.ncbi.nlm.nih.gov/pubmed/25699710
http://dx.doi.org/10.1016/j.molcel.2015.01.011

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