Cargando…

Transport domain unlocking sets the uptake rate of an aspartate transporter

Glutamate transporters terminate neurotransmission by clearing synaptically released glutamate from the extracellular space, allowing repeated rounds of signaling and preventing glutamate-mediated excitotoxicity. Crystallographic studies on an archaeal homologue, Glt(Ph), showed that distinct transp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akyuz, Nurunisa, Georgieva, Elka R., Zhou, Zhou, Stolzenberg, Sebastian, Cuendet, Michel A., Khelashvili, George, Altman, Roger B., Terry, Daniel S., Freed, Jack H., Weinstein, Harel, Boudker, Olga, Blanchard, Scott C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351760/ https://www.ncbi.nlm.nih.gov/pubmed/25652997 http://dx.doi.org/10.1038/nature14158

Ejemplares similares

Transport dynamics in a glutamate transporter homologue
por: Akyuz, Nurunisa, et al.
Publicado: (2013)

Conformational ensemble of the sodium coupled aspartate transporter
por: Georgieva, Elka R., et al.
Publicado: (2013)

A facile approach for the in vitro assembly of multimeric membrane transport proteins
por: Riederer, Erika A, et al.
Publicado: (2018)

Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh
por: Stolzenberg, Sebastian, et al.
Publicado: (2012)

A partially-open inward-facing intermediate conformation of LeuT is associated with Na(+) release and substrate transport
por: Terry, Daniel S., et al.
Publicado: (2018)

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor
por: LeVine, Michael V., et al.
Publicado: (2019)

A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter
por: Razavi, Asghar M., et al.
Publicado: (2017)

How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties
por: Razavi, Asghar M., et al.
Publicado: (2018)

Single-molecule transport kinetics of a glutamate transporter homolog shows static disorder
por: Ciftci, Didar, et al.
Publicado: (2020)

Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles
por: LeVine, Michael V., et al.
Publicado: (2016)

Single-molecule dynamics of gating in a neurotransmitter transporter homolog
por: Zhao, Yongfang, et al.
Publicado: (2010)

Use of Paramagnetic (19)F NMR to Monitor Domain Movement in a Glutamate Transporter
por: Huang, Yun, et al.
Publicado: (2020)

Substrate-modulated gating dynamics in a Na(+)-coupled neurotransmitter transporter homolog
por: Zhao, Yongfang, et al.
Publicado: (2011)

Symport and antiport mechanisms of human glutamate transporters
por: Qiu, Biao, et al.
Publicado: (2023)

The high‐energy transition state of the glutamate transporter homologue GltPh
por: Huysmans, Gerard H M, et al.
Publicado: (2020)

Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP(2)-Regulated Dynamics of the N-Terminus
por: Khelashvili, George, et al.
Publicado: (2015)

Coupled ion binding and structural transitions along the transport cycle of glutamate transporters
por: Verdon, Grégory, et al.
Publicado: (2014)

Improved Sensitivity for Long-Distance Measurements in Biomolecules: Five-Pulse Double Electron–Electron Resonance
por: Borbat, Peter P., et al.
Publicado: (2012)

Elucidating the Mechanism of Membrane Destabilization by the Preferred Modes of Insertion of the Sars-Cov2 Fusion Peptide
por: Khelashvili, George, et al.
Publicado: (2021)

Binding and transport of D-aspartate by the glutamate transporter homolog Glt(Tk)
por: Arkhipova, Valentina, et al.
Publicado: (2019)

Isothermal titration calorimetry of ion-coupled membrane transporters
por: Boudker, Olga, et al.
Publicado: (2015)

Binding thermodynamics of a glutamate transporter homologue
por: Reyes, Nicolas, et al.
Publicado: (2013)

Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh
por: Oh, SeCheol, et al.
Publicado: (2018)

Linking function to global and local dynamics in an elevator-type transporter
por: Ciftci, Didar, et al.
Publicado: (2021)

Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport
por: Qiu, Biao, et al.
Publicado: (2021)

Unlocking the secrets of peptide transport in wine yeast: insights into oligopeptide transporter functions and nitrogen source preferences
por: Berg, Hidde Yaël, et al.
Publicado: (2023)

Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters
por: Wang, Xiaoyu, et al.
Publicado: (2020)

Protein Diffusion on Charged Membranes: A Dynamic Mean-Field Model Describes Time Evolution and Lipid Reorganization
por: Khelashvili, George, et al.
Publicado: (2008)

Phosphatidylinositol 4,5-Biphosphate (PIP(2)) Lipids Regulate the Phosphorylation of Syntaxin N-Terminus by Modulating Both Its Position and Local Structure
por: Khelashvili, George, et al.
Publicado: (2012)

Not Just an Oil Slick: How the Energetics of Protein-Membrane Interactions Impacts the Function and Organization of Transmembrane Proteins
por: Mondal, Sayan, et al.
Publicado: (2014)

The permeation of potassium ions through the lipid scrambling path of the membrane protein nhTMEM16
por: Cheng, Xiaolu, et al.
Publicado: (2022)

Mechanism of influenza A M2 transmembrane domain assembly in lipid membranes
por: Georgieva, Elka R., et al.
Publicado: (2015)

Unlocking the potentials of nitrate transporters at improving plant nitrogen use efficiency
por: Aluko, Oluwaseun Olayemi, et al.
Publicado: (2023)

The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters
por: Aseervatham, Jaya, et al.
Publicado: (2015)

The Outer Pore and Selectivity Filter of TRPA1
por: Christensen, Adam P., et al.
Publicado: (2016)

Millisecond dynamics of an unlabeled amino acid transporter
por: Matin, Tina R., et al.
Publicado: (2020)

Oligomeric state of the aspartate:alanine transporter from Tetragenococcus halophilus
por: Miyamoto, Akari, et al.
Publicado: (2022)

Position of the Third Na(+) Site in the Aspartate Transporter Glt(Ph) and the Human Glutamate Transporter, EAAT1
por: Bastug, Turgut, et al.
Publicado: (2012)

Structural basis for membrane anchoring and fusion regulation of the Herpes Simplex Virus fusogen gB
por: Cooper, Rebecca S., et al.
Publicado: (2018)

Ca(2+)-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide
por: Khelashvili, George, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e7ucf8dc78bb96ibol0plgut4d