Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan
A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which is geographically adjacent to China, faces a larg...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351886/ https://www.ncbi.nlm.nih.gov/pubmed/25748033 http://dx.doi.org/10.1371/journal.pone.0119792 |
_version_ | 1782360372262469632 |
---|---|
author | Yang, Ji-Rong Kuo, Chuan-Yi Huang, Hsiang-Yi Wu, Fu-Ting Huang, Yi-Lung Cheng, Chieh-Yu Su, Yu-Ting Wu, Ho-Sheng Liu, Ming-Tsan |
author_facet | Yang, Ji-Rong Kuo, Chuan-Yi Huang, Hsiang-Yi Wu, Fu-Ting Huang, Yi-Lung Cheng, Chieh-Yu Su, Yu-Ting Wu, Ho-Sheng Liu, Ming-Tsan |
author_sort | Yang, Ji-Rong |
collection | PubMed |
description | A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which is geographically adjacent to China, faces a large risk of being affected by this virus. Through extensive surveillance, launched in April 2013, four laboratory-confirmed H7N9 cases imported from China have been identified in Taiwan. The H7N9 virus isolated from imported case 1 in May 2013 (during the first wave) was found to be closest genetically to a virus from wild birds and differed from the prototype virus, A/Anhui/1/2013, in the MP gene. The other three imported cases were detected in December 2013 and April 2014 (during the second wave). The viruses isolated from cases 2 and 4 were similar in the compositions of their 6 internal genes and distinct from A/Anhui/1/2013 in the PB2 and MP genes, whereas the virus isolated from case 3 exhibited a novel reassortment that has not been identified previously and was different from A/Anhui/1/2013 in the PB2, PA and MP genes. The four imported H7N9 viruses share similar antigenicity with A/Anhui/1/2013, and their HA and NA genes grouped together in their respective phylogenies. In contrast with the HA and NA genes, which exhibited a smaller degree of diversity, the internal genes were heterogeneous and provided potential distinctions between transmission sources in terms of both geography and hosts. It is important to strengthen surveillance of influenza and to share viral genetic data in real-time for reducing the threat of rapid and continuing evolution of H7N9 viruses. |
format | Online Article Text |
id | pubmed-4351886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43518862015-03-17 Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan Yang, Ji-Rong Kuo, Chuan-Yi Huang, Hsiang-Yi Wu, Fu-Ting Huang, Yi-Lung Cheng, Chieh-Yu Su, Yu-Ting Wu, Ho-Sheng Liu, Ming-Tsan PLoS One Research Article A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which is geographically adjacent to China, faces a large risk of being affected by this virus. Through extensive surveillance, launched in April 2013, four laboratory-confirmed H7N9 cases imported from China have been identified in Taiwan. The H7N9 virus isolated from imported case 1 in May 2013 (during the first wave) was found to be closest genetically to a virus from wild birds and differed from the prototype virus, A/Anhui/1/2013, in the MP gene. The other three imported cases were detected in December 2013 and April 2014 (during the second wave). The viruses isolated from cases 2 and 4 were similar in the compositions of their 6 internal genes and distinct from A/Anhui/1/2013 in the PB2 and MP genes, whereas the virus isolated from case 3 exhibited a novel reassortment that has not been identified previously and was different from A/Anhui/1/2013 in the PB2, PA and MP genes. The four imported H7N9 viruses share similar antigenicity with A/Anhui/1/2013, and their HA and NA genes grouped together in their respective phylogenies. In contrast with the HA and NA genes, which exhibited a smaller degree of diversity, the internal genes were heterogeneous and provided potential distinctions between transmission sources in terms of both geography and hosts. It is important to strengthen surveillance of influenza and to share viral genetic data in real-time for reducing the threat of rapid and continuing evolution of H7N9 viruses. Public Library of Science 2015-03-06 /pmc/articles/PMC4351886/ /pubmed/25748033 http://dx.doi.org/10.1371/journal.pone.0119792 Text en © 2015 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Yang, Ji-Rong Kuo, Chuan-Yi Huang, Hsiang-Yi Wu, Fu-Ting Huang, Yi-Lung Cheng, Chieh-Yu Su, Yu-Ting Wu, Ho-Sheng Liu, Ming-Tsan Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan |
title | Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan |
title_full | Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan |
title_fullStr | Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan |
title_full_unstemmed | Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan |
title_short | Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan |
title_sort | characterization of influenza a (h7n9) viruses isolated from human cases imported into taiwan |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351886/ https://www.ncbi.nlm.nih.gov/pubmed/25748033 http://dx.doi.org/10.1371/journal.pone.0119792 |
work_keys_str_mv | AT yangjirong characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan AT kuochuanyi characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan AT huanghsiangyi characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan AT wufuting characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan AT huangyilung characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan AT chengchiehyu characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan AT suyuting characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan AT wuhosheng characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan AT liumingtsan characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan |