Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan

A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which is geographically adjacent to China, faces a larg...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Ji-Rong, Kuo, Chuan-Yi, Huang, Hsiang-Yi, Wu, Fu-Ting, Huang, Yi-Lung, Cheng, Chieh-Yu, Su, Yu-Ting, Wu, Ho-Sheng, Liu, Ming-Tsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351886/
https://www.ncbi.nlm.nih.gov/pubmed/25748033
http://dx.doi.org/10.1371/journal.pone.0119792
_version_ 1782360372262469632
author Yang, Ji-Rong
Kuo, Chuan-Yi
Huang, Hsiang-Yi
Wu, Fu-Ting
Huang, Yi-Lung
Cheng, Chieh-Yu
Su, Yu-Ting
Wu, Ho-Sheng
Liu, Ming-Tsan
author_facet Yang, Ji-Rong
Kuo, Chuan-Yi
Huang, Hsiang-Yi
Wu, Fu-Ting
Huang, Yi-Lung
Cheng, Chieh-Yu
Su, Yu-Ting
Wu, Ho-Sheng
Liu, Ming-Tsan
author_sort Yang, Ji-Rong
collection PubMed
description A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which is geographically adjacent to China, faces a large risk of being affected by this virus. Through extensive surveillance, launched in April 2013, four laboratory-confirmed H7N9 cases imported from China have been identified in Taiwan. The H7N9 virus isolated from imported case 1 in May 2013 (during the first wave) was found to be closest genetically to a virus from wild birds and differed from the prototype virus, A/Anhui/1/2013, in the MP gene. The other three imported cases were detected in December 2013 and April 2014 (during the second wave). The viruses isolated from cases 2 and 4 were similar in the compositions of their 6 internal genes and distinct from A/Anhui/1/2013 in the PB2 and MP genes, whereas the virus isolated from case 3 exhibited a novel reassortment that has not been identified previously and was different from A/Anhui/1/2013 in the PB2, PA and MP genes. The four imported H7N9 viruses share similar antigenicity with A/Anhui/1/2013, and their HA and NA genes grouped together in their respective phylogenies. In contrast with the HA and NA genes, which exhibited a smaller degree of diversity, the internal genes were heterogeneous and provided potential distinctions between transmission sources in terms of both geography and hosts. It is important to strengthen surveillance of influenza and to share viral genetic data in real-time for reducing the threat of rapid and continuing evolution of H7N9 viruses.
format Online
Article
Text
id pubmed-4351886
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-43518862015-03-17 Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan Yang, Ji-Rong Kuo, Chuan-Yi Huang, Hsiang-Yi Wu, Fu-Ting Huang, Yi-Lung Cheng, Chieh-Yu Su, Yu-Ting Wu, Ho-Sheng Liu, Ming-Tsan PLoS One Research Article A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which is geographically adjacent to China, faces a large risk of being affected by this virus. Through extensive surveillance, launched in April 2013, four laboratory-confirmed H7N9 cases imported from China have been identified in Taiwan. The H7N9 virus isolated from imported case 1 in May 2013 (during the first wave) was found to be closest genetically to a virus from wild birds and differed from the prototype virus, A/Anhui/1/2013, in the MP gene. The other three imported cases were detected in December 2013 and April 2014 (during the second wave). The viruses isolated from cases 2 and 4 were similar in the compositions of their 6 internal genes and distinct from A/Anhui/1/2013 in the PB2 and MP genes, whereas the virus isolated from case 3 exhibited a novel reassortment that has not been identified previously and was different from A/Anhui/1/2013 in the PB2, PA and MP genes. The four imported H7N9 viruses share similar antigenicity with A/Anhui/1/2013, and their HA and NA genes grouped together in their respective phylogenies. In contrast with the HA and NA genes, which exhibited a smaller degree of diversity, the internal genes were heterogeneous and provided potential distinctions between transmission sources in terms of both geography and hosts. It is important to strengthen surveillance of influenza and to share viral genetic data in real-time for reducing the threat of rapid and continuing evolution of H7N9 viruses. Public Library of Science 2015-03-06 /pmc/articles/PMC4351886/ /pubmed/25748033 http://dx.doi.org/10.1371/journal.pone.0119792 Text en © 2015 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yang, Ji-Rong
Kuo, Chuan-Yi
Huang, Hsiang-Yi
Wu, Fu-Ting
Huang, Yi-Lung
Cheng, Chieh-Yu
Su, Yu-Ting
Wu, Ho-Sheng
Liu, Ming-Tsan
Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan
title Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan
title_full Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan
title_fullStr Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan
title_full_unstemmed Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan
title_short Characterization of Influenza A (H7N9) Viruses Isolated from Human Cases Imported into Taiwan
title_sort characterization of influenza a (h7n9) viruses isolated from human cases imported into taiwan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351886/
https://www.ncbi.nlm.nih.gov/pubmed/25748033
http://dx.doi.org/10.1371/journal.pone.0119792
work_keys_str_mv AT yangjirong characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan
AT kuochuanyi characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan
AT huanghsiangyi characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan
AT wufuting characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan
AT huangyilung characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan
AT chengchiehyu characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan
AT suyuting characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan
AT wuhosheng characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan
AT liumingtsan characterizationofinfluenzaah7n9virusesisolatedfromhumancasesimportedintotaiwan