Apc and p53 interaction in DNA damage and genomic instability in hepatocytes

Disruption of Apc within hepatocytes activates Wnt signaling, perturb differentiation and ultimately lead to neoplasia. Apc negatively regulates Wnt signaling but is also involved in organizing the cytoskeleton and may play a role in chromosome segregation. In vitro studies have implicated Apc in th...

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Detalles Bibliográficos
Autores principales: Méniel, Valérie, Megges, Matthias, Young, Madeleine A, Cole, Alicia, Sansom, Owen J, Clarke, Alan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351894/
https://www.ncbi.nlm.nih.gov/pubmed/25347740
http://dx.doi.org/10.1038/onc.2014.342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351894/
https://www.ncbi.nlm.nih.gov/pubmed/25347740
http://dx.doi.org/10.1038/onc.2014.342

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