Deconvoluting the Composition of Low-Frequency Hepatitis C Viral Quasispecies: Comparison of Genotypes and NS3 Resistance-Associated Variants between HCV/HIV Coinfected Hemophiliacs and HCV Monoinfected Patients in Japan

Pre-existing low-frequency resistance-associated variants (RAVs) may jeopardize successful sustained virological responses (SVR) to HCV treatment with direct-acting antivirals (DAAs). However, the potential impact of low-frequency (∼0.1%) mutations, concatenated mutations (haplotypes), and their ass...

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Detalles Bibliográficos
Autores principales: Ogishi, Masato, Yotsuyanagi, Hiroshi, Tsutsumi, Takeya, Gatanaga, Hiroyuki, Ode, Hirotaka, Sugiura, Wataru, Moriya, Kyoji, Oka, Shinichi, Kimura, Satoshi, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351984/
https://www.ncbi.nlm.nih.gov/pubmed/25748426
http://dx.doi.org/10.1371/journal.pone.0119145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351984/
https://www.ncbi.nlm.nih.gov/pubmed/25748426
http://dx.doi.org/10.1371/journal.pone.0119145

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