Loss of Anticodon Wobble Uridine Modifications Affects tRNA(Lys) Function and Protein Levels in Saccharomyces cerevisiae

In eukaryotes, wobble uridines in the anticodons of tRNA(Lys) (UUU), tRNA(Glu) (UUC) and tRNA(Gln) (UUG) are modified to 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm(5)s(2)U). While mutations in subunits of the Elongator complex (Elp1-Elp6), which disable mcm(5) side chain formation, or removal of...

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Detalles Bibliográficos
Autores principales: Klassen, Roland, Grunewald, Pia, Thüring, Kathrin L., Eichler, Christian, Helm, Mark, Schaffrath, Raffael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352028/
https://www.ncbi.nlm.nih.gov/pubmed/25747122
http://dx.doi.org/10.1371/journal.pone.0119261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352028/
https://www.ncbi.nlm.nih.gov/pubmed/25747122
http://dx.doi.org/10.1371/journal.pone.0119261

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