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Loss of Anticodon Wobble Uridine Modifications Affects tRNA(Lys) Function and Protein Levels in Saccharomyces cerevisiae
In eukaryotes, wobble uridines in the anticodons of tRNA(Lys) (UUU), tRNA(Glu) (UUC) and tRNA(Gln) (UUG) are modified to 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm(5)s(2)U). While mutations in subunits of the Elongator complex (Elp1-Elp6), which disable mcm(5) side chain formation, or removal of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352028/ https://www.ncbi.nlm.nih.gov/pubmed/25747122 http://dx.doi.org/10.1371/journal.pone.0119261 |