Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

Cerebellar symptoms significantly diminish quality of life in patients with multiple sclerosis (MS). We previously showed that sodium channel Nav1.8, although normally restricted to peripheral somatosensory neurons, is upregulated in the cerebellum in MS, and that Nav1.8 expression is linked to atax...

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Detalles Bibliográficos
Autores principales: Shields, Shannon D., Butt, Richard P., Dib-Hajj, Sulayman D., Waxman, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352054/
https://www.ncbi.nlm.nih.gov/pubmed/25747279
http://dx.doi.org/10.1371/journal.pone.0119067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352054/
https://www.ncbi.nlm.nih.gov/pubmed/25747279
http://dx.doi.org/10.1371/journal.pone.0119067

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