Phospholipid-modified PEI-based nanocarriers for in vivo siRNA therapeutics against multi-drug resistant tumors

Multidrug resistance (MDR) mediated by P-glycoprotein overexpression in solid tumors is a major factor in the failure of many forms of chemotherapy. Here, we evaluated phospholipid-modified, low molecular weight polyethylenimine (DOPE-PEI) nanocarriers for intravenous delivery of anti-P-pg siRNA to...

Descripción completa

Detalles Bibliográficos
Autores principales: Essex, Sean, Navarro, Gemma, Sabhachandani, Pooja, Chordia, Aabha, Trivedi, Malav, Movassaghian, Sara, Torchilin, Vladimir P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352110/
https://www.ncbi.nlm.nih.gov/pubmed/25354685
http://dx.doi.org/10.1038/gt.2014.97

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352110/
https://www.ncbi.nlm.nih.gov/pubmed/25354685
http://dx.doi.org/10.1038/gt.2014.97

Ejemplares similares