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Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy)

BACKGROUND: Chloroquine (CQ) and hydroxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Both drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retinopathy. Established risk f...

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Detalles Bibliográficos
Autores principales: Grassmann, Felix, Bergholz, Richard, Mändl, Julia, Jägle, Herbert, Ruether, Klaus, Weber, Bernhard HF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352241/
https://www.ncbi.nlm.nih.gov/pubmed/25884411
http://dx.doi.org/10.1186/s12886-015-0008-0