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Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy)
BACKGROUND: Chloroquine (CQ) and hydroxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Both drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retinopathy. Established risk f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352241/ https://www.ncbi.nlm.nih.gov/pubmed/25884411 http://dx.doi.org/10.1186/s12886-015-0008-0 |